When should children with pediatric HIV infection receive a tetanus, diphtheria, and pertussis (Tdap) vaccination?

Updated: Mar 05, 2020
  • Author: Delia M Rivera, MD; Chief Editor: Russell W Steele, MD  more...
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Answer

Use of the combined tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccines (Tdap) is not contraindicated in HIV-infected children. The immunogenicity of Tdap in persons with immunosuppression has not been studied and could be suboptimal. Tdap can be administered to children and adolescents aged 11-18 years at an interval of less than 5 years after Td vaccination, as the benefit of providing protection against pertussis is likely to be increased. Data from a Canadian study of children and adolescents support the safety of an interval as short as about 2 years between Td and Tdap vaccinations.


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