Which children with pediatric HIV infection should receive a varicella vaccination and which vaccine should be used?

Updated: Mar 05, 2020
  • Author: Delia M Rivera, MD; Chief Editor: Russell W Steele, MD  more...
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Answer

Administer 2 doses of single-antigen varicella vaccine at a minimum interval of 3 months to HIV-infected children 12 months of age or older in CDC clinical class N, A, or B with CD4+ T-lymphocyte counts 15% or higher and without evidence of varicella. Varicella vaccine was previously recommended for asymptomatic or mildly symptomatic HIV-infected children (CDC clinical class N or A) with age-specific CD4+ T-lymphocyte counts of 25% or higher. Otherwise, varicella vaccination is strictly forbidden, and exposure to varicella should be treated with intramuscular (IM) varicella-zoster immunoglobulin within 72 hours of exposure.


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