What is the CDC-approved regimen to reduce vertical transmission of pediatric HIV infection?

Updated: Mar 05, 2020
  • Author: Delia M Rivera, MD; Chief Editor: Russell W Steele, MD  more...
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Answer

The CDC has approved the following regimen to reduce vertical HIV transmission:

  • Antepartum: Administer zidovudine 300 mg orally (PO) twice a day and other appropriate ART, usually the addition of lamivudine and lopinavir/ritonavir. For women who present during the prenatal period, zidovudine should be started regardless of the use of other antiretroviral agents and a history of zidovudine resistance

  • Intrapartum: Continuously infuse zidovudine intravenously (IV) at a rate of 1 mg/kg/hour for women who present in labor

  • Neonates: Give zidovudine, starting within the first 6-12 hours of life and continuing until the patient is 6 weeks old


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