How common is neutropenia in pediatric HIV infection, and which myelosuppressive drugs can induce neutropenia?

Updated: Mar 05, 2020
  • Author: Delia M Rivera, MD; Chief Editor: Russell W Steele, MD  more...
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Answer

Neutropenia is relatively common in advanced HIV disease. In 25% of patients with moderate neutropenia, bacterial infections develop, most often within 24 hours of the onset of neutropenia. The following myelosuppressive drugs—especially zidovudine, trimethoprim-sulfamethoxazole, and ganciclovir—can induce neutropenia:

  • Zidovudine

  • Lamivudine

  • Didanosine

  • Stavudine

  • Ganciclovir

  • Valganciclovir

  • Foscarnet

  • Flucytosine

  • Amphotericin

  • Sulfonamides

  • Trimethoprim, trimethoprim-sulfamethoxazole

  • Pyrimethamine

  • Pentamidine


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