How can long-lasting responses be achieved for thrombocytopenia in pediatric HIV infection?

Updated: Mar 05, 2020
  • Author: Delia M Rivera, MD; Chief Editor: Russell W Steele, MD  more...
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Answer

More long-lasting responses can be achieved with zidovudine or danazol treatment or splenectomy. In most adults, high-dose zidovudine can reverse HIV-related idiopathic thrombocytopenia purpura (HIV-ITP). Treatment of HIV infection, especially with zidovudine, appears to improve the platelet count and platelet production. In adults, danazol 400-800 mg daily increases the platelet count in 1-2 months.

Splenectomy is an effective long-term treatment. Although splenectomy is not associated with an increased mortality rate, the risk of fulminant infections with encapsulated bacteria increases.


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