Which regimens are used to increase platelet count in thrombocytopenia in Rh-positive patients with pediatric HIV infection?

Updated: Mar 05, 2020
  • Author: Delia M Rivera, MD; Chief Editor: Russell W Steele, MD  more...
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Answer

Anti-Rh immunoglobulin is useful in Rh-positive patients who have not undergone splenectomy, and it is relatively inexpensive. A 1- to 2-g decrease in the hemoglobin level occurs, which limits use of this therapy in patients with anemia. In most patients, 25 mcg/kg administered IV on 2 consecutive days with repeated doses of IV anti-Rh or intramuscular (IM) anti-D every 2-4 weeks increases the platelet count. As an alternative, 6-13 mcg/kg IM administered every week also produces a reasonable increase in the platelet count.


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