Which regimens are used to increase platelet count in thrombocytopenia in pediatric HIV infection?

Updated: Mar 05, 2020
  • Author: Delia M Rivera, MD; Chief Editor: Russell W Steele, MD  more...
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Answer

The platelet count may transiently increase with IV immunoglobulin (IVIG), interferon (IFN)-alfa, corticosteroids, or anti-Rh immunoglobulin. IVIG is the treatment of choice. Regimens include IVIG 1-2 g/kg/day for 2-5 days. Three million units of IFN-alfa administered 3 times per week increases the platelet count in 50% of adults after 3 weeks. A 4-week course of prednisone 1-2 mg/kg followed by a 2- to 4-week taper is an alternative, but the immunosuppressive adverse effects must be considered carefully.


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