When is immunologic function assessment indicated in pediatric HIV infection and which tests are included?

Updated: Mar 05, 2020
  • Author: Delia M Rivera, MD; Chief Editor: Russell W Steele, MD  more...
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Answer

Immunologic function should be assessed in high-risk patients. Immunoglobulin levels should be checked every 3-6 months. Hypogammaglobulinemia is defined as an immunoglobulin G level of less than 2.5 g/L.

Humoral immune function can be checked by measuring specific antibody titers after immunization. Cellular immune function is checked by using a subcutaneous candidal control.

Children with hypogammaglobulinemia, humoral immune dysfunction, or more than 2 serious bacterial infections in a year should be given intravenous immunoglobulin (IVIG) 400 mg/kg every 4 weeks.


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