What is the treatment for M avium-intracellulare complex (MAC) infection in pediatric HIV infection?

Updated: Mar 05, 2020
  • Author: Delia M Rivera, MD; Chief Editor: Russell W Steele, MD  more...
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Answer

Control of a MAC infection requires at least 2 or 3 antibiotics, but more may be necessary if clinical symptoms do not resolve. Early detection and treatment is most effective.

Exposure to antibiotics before treatment suggests that other agents may be more effective than those previously used. In addition, a lack of a response to a regimen may indicate the need to empirically change antibiotics instead of simply adding antibiotics, as drug resistance can develop rapidly. Although polyantimicrobial therapy may be useful, toxicity is more common with this approach.


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