Is efavirenz effective in the treatment of pediatric HIV infection in children who are also being treated for tuberculosis (TB)?

Updated: Mar 05, 2020
  • Author: Delia M Rivera, MD; Chief Editor: Russell W Steele, MD  more...
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Efavirenz is effective against HIV in children who are also being treated for TB, according to a study by van Dijk et al. The study population consisted of 114 HIV-infected children younger than 3 years of age or weighing less than 10 kg: 45 children who were also being treated for TB received an efavirenz-based ART regimen; a second group of 69 children, including 7 who were being treated for TB, received an ART regimen using nevirapine.

At the initiation of ART, the children treated with efavirenz had a lower CD4+ percentage and weight-for-age z-score than did the nevirapine group. Nevertheless, improvement with the efavirenz-based regimen was such that the CD4+ percentage and z-score for both groups were comparable at 2-year follow-up. [55]

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