What is the treatment for mycobacterial infection in pediatric HIV infection?

Updated: Mar 05, 2020
  • Author: Delia M Rivera, MD; Chief Editor: Russell W Steele, MD  more...
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Answer

Initial therapy should involve 4 drugs: isoniazid, rifampin or rifabutin, pyrazinamide, and ethambutol or streptomycin. Therapy should continue for 1 year if the isolate is drug susceptible or more than 1 year if the isolate is multidrug resistant. Rifampin and rifabutin interact with protease inhibitors, requiring an alteration in HAART. Children younger than 4 years should not be treated with ethambutol because of possible optic neuritis.


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