What is the role of Pneumocystis pneumonia (PCP) prophylaxis in pediatric HIV infection?

Updated: Mar 05, 2020
  • Author: Delia M Rivera, MD; Chief Editor: Russell W Steele, MD  more...
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Prophylaxis is the most important measure for decreasing the incidence of PCP, it but does not guarantee protection. Table 4 below delineates the CD4+ indications for starting prophylaxis with regard to the patient's age or status.

Table 4. CD4+ -Based Indications for Starting PCP Prophylaxis (Open Table in a new window)

Age or Status

CD4+ Count, cells/mL

CD4+ Percentage

6 wk to 1 y



1-2 y

< 750

< 15

2-5 y

< 500

< 15

>5 y

< 200

< 15

Previous PCP infection



PCP prophylaxis should be started in all infants aged 6 weeks who were born to HIV-infected mothers. It should be continued until HIV infection has been ruled out.

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