What may immune reconstitution inflammatory syndrome (IRIS) unmask in pediatric HIV infection?

Updated: Mar 05, 2020
  • Author: Delia M Rivera, MD; Chief Editor: Russell W Steele, MD  more...
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Answer

IRIS may unmask viable pathogens. Alternatively, in so-called paradoxical IRIS, symptomatic relapse reflects reconstitution of specific T-cell–mediated immunity against persisting antigens from dead organisms; cultures in these cases are sterile. [38]


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