What is the relationship between highly active antiretroviral therapy (HAART) and immune reconstitution inflammatory syndrome (IRIS) in pediatric HIV infection?

Updated: Mar 05, 2020
  • Author: Delia M Rivera, MD; Chief Editor: Russell W Steele, MD  more...
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Answer

OIs are typically an indication of severe immune suppression. However, an increased capacity to mount inflammatory reactions as a result of successful HAART may result in the development of immune reconstitution inflammatory syndrome (IRIS), which manifests as worsening of an existing active, latent, or occult OI. Although IRIS has primarily been reported in adults after initiation of HAART, it also has been reported in children.


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