What constitutes immunologic treatment failure in pediatric HIV infection?

Updated: Mar 05, 2020
  • Author: Delia M Rivera, MD; Chief Editor: Russell W Steele, MD  more...
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Answer

Immunologic failure includes incomplete response and immunologic decline. Incomplete response is defined as a failure by a child younger than 5 years with severe immune suppression (CD4+< 15%) to improve CD4+ values by 5 or more percentage points, or as a failure by a child aged 5 years or older with severe immunosuppression (CD4+< 200 cells/µL) to improve CD4+ values by 50 cells/µL or greater above baseline within the first year of therapy


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