What constitutes virologic treatment failure in pediatric HIV infection?

Updated: Mar 05, 2020
  • Author: Delia M Rivera, MD; Chief Editor: Russell W Steele, MD  more...
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Answer

Virologic failure includes incomplete response and viral rebound. Incomplete virologic response to therapy is defined for all children with any of the following:

  • A less than 1.010 decrease in HIV RNA copy number from baseline after 8–12 weeks of therapy,

  • HIV RNA of greater than 400 copies/µL after 6 months of therapy

  • Repeated HIV RNA levels above the level of detection after 12 months of therapy (However, children with very high viral load levels may take longer to go to undetectable levels.)


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