What are preferred antiretroviral therapy (ART) combination regimens and alternative regimens for pediatric HIV infection?

Updated: Mar 05, 2020
  • Author: Delia M Rivera, MD; Chief Editor: Russell W Steele, MD  more...
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Answer

Preferred regimens are as follows:

  • Infants, birth to < 14 days: 2 NRTIs plus nevirapine

  • Aged ≥14 days to < 3 years: 2 NRTIs plus lopinavir/ritonavir

  • Aged ≥2 years to < 3 years: 2 NRTIs plus  lopinavir/ritonavir or 2 NRTIs plus raltegravir

  • Aged ≥3 years to < 6 years: 2 NRTIs plus  atazanavir/ritonavir or 2 NRTIs plus  twice daily darunavir/ritonavir or 2 NRTIS plus raltegravir

  • Aged ≥6 years to < 12 years: 2 NRTIs plus  atazanavir/ritonavir or 2 NRTIs plus dolutegravir

  • Adolescents aged >12 years and not sexually mature: 2 NRTIs plus  atazanavir/ritonavir or 2 NRTIs plus  dolutegravir or 2 NRTIs plus  once daily darunavir/ritonavir or 2 NRTIs plus elvitegravir/cobicistat

  • Adolescents aged >12 years and sexually mature: Refer to adult and adolescent guidelines

See the full Guidelines for the Use of Antiretroviral Agents in Pediatric HIV Infection for additional information including alternant ART regimens


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