Which complete antiretroviral therapy (ART) regimens are available for HIV-1 infection in adults and children aged 12 years or older?

Updated: Mar 05, 2020
  • Author: Delia M Rivera, MD; Chief Editor: Russell W Steele, MD  more...
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Answer

The combination product Genvoya (elvitegravir/cobicistat/emtricitabine/tenofovir AF) was approved in 2015 as a complete treatment regimen for HIV-1 infection in adults and children aged ≥12 y (weight ≥35 kg) who are ART-naïve or to replace the current ART regimen in those who are virologically suppressed (HIV-1 RNA < 50 copies/mL) on a stable ART regimen for at least 6 months with no history of treatment failure and no known substitutions associated with resistance to the individual components. [49]

In February 2016, emtricitabine/rilpivirine/tenofovir DF (Complera) was approved as complete regimen for treatment of HIV-1 infection in treatment-naïve adults and adolescents aged 12 years or older (weight ≥35 kg) with HIV-1 RNA >100,000 copies/mL, and in certain virologically-suppressed (HIV-1 RNA < 50 copies/mL) patients on a stable ART regimen at start of therapy in order to replace their current ART regimen. [50]


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