What is the role of dolutegravir in the treatment of pediatric HIV infection?

Updated: Mar 05, 2020
  • Author: Delia M Rivera, MD; Chief Editor: Russell W Steele, MD  more...
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Answer

The integrase strand transfer inhibitor dolutegravir is indicated as an adjunct agent for patients with HIV-1 infection. Dolutegravir, which interferes with an enzyme needed for HIV to multiply, is a once-daily pill used in combination with other antiretroviral drugs. Pediatric indications are for children who weigh at least 30 kg and are treatment-naïve or, if they are treatment-experienced, have not previously taken other integrase strand transfer inhibitors. [44, 45]


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