What is the recommended initial antiretroviral therapy (ART) regimen in infants, children, and adolescents with pediatric HIV infection?

Updated: Mar 05, 2020
  • Author: Delia M Rivera, MD; Chief Editor: Russell W Steele, MD  more...
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Combination ART with at least 3 drugs from at least 2 classes of drugs is recommended for initial treatment of infected infants, children, and adolescents because it provides the best opportunity to preserve immune function and delay disease progression.

The use of zidovudine as a single agent is appropriate only when used in infants of indeterminate HIV status during the first 6 weeks of life to prevent perinatal HIV transmission. Infants confirmed as HIV infected while receiving chemoprophylaxis should have prophylactic antiretroviral drugs discontinued and treatment initiated, with a combination regimen of at least 3 drugs.

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