What are the age-related CD4 thresholds for initiating antiretroviral therapy (ART) in pediatric HIV infection?

Updated: Mar 05, 2020
  • Author: Delia M Rivera, MD; Chief Editor: Russell W Steele, MD  more...
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Answer

For patients aged 1 year or older, the age-related CD4 thresholds for initiating treatment are less than 25% for children aged 1-4 years and less than 350 cells/μL for children aged 5 years or older, regardless of symptoms or plasma HIV RNA level.

Initiate treatment in children aged 1 year or older who are asymptomatic or have mild symptoms and have a CD4 of 25% or more in children aged 1-4 years or 350 cells/μL or more in children aged 5 years or older who have plasma HIV RNA of 100,000 copies/mL or more.


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