How effective is early antiretroviral therapy (ART) for HIV infection in children younger than 12 months (1 year)?

Updated: Mar 05, 2020
  • Author: Delia M Rivera, MD; Chief Editor: Russell W Steele, MD  more...
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Answer

The importance of early treatment of HIV in children younger than 12 months was illustrated in the Children with HIV Early Antiretroviral Therapy trial, which showed a 76% reduction in infant mortality and a 75% reduction in HIV progression with the early initiation of treatment. [40]  The case of a 9-year-old South African girl from this trial by Violari et al [40] was presented at the International AIDS Society 2017 Conference as the third case of long-term pediatric HIV remission after short antiretroviral treatment  At HIV diagnosis when she was 32 days old, a viral load of 750,000 copies/mL was reported. The viral load dropped to 151,000 copies/mL at initiation of antiretroviral therapy and soon after dropped to 915 copies/mL. At 40 weeks old the viral load was below 20 copies/mL and remains undetectable to date. [41]


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