What are the classes of antiretroviral drugs used in pediatric HIV infection?

Updated: Mar 05, 2020
  • Author: Delia M Rivera, MD; Chief Editor: Russell W Steele, MD  more...
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Answer

Advances in medical management have dramatically reduced morbidity and mortality in children with in HIV in the United States. [39]  Many antiretroviral drugs are approved for children and some are approved for infants and neonates. There are also varying formulations (eg, oral liquids) or capsule sizes that accommodate pediatric dosing. Classes of antiretroviral agents include the following:

  • Nucleoside or nucleotide reverse transcriptase inhibitors (NRTIs)

  • Protease inhibitors (PIs)

  • Nonnucleoside reverse transcriptase inhibitors (NNRTIs)

  • Fusion inhibitors

  • CCR5 co-receptor antagonists (entry inhibitors)

  • HIV integrase strand transfer inhibitors


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