Which factors are important to consider in pediatric HIV infection treatment decisions about when to initiate antiretroviral therapy (ART)?

Updated: Mar 05, 2020
  • Author: Delia M Rivera, MD; Chief Editor: Russell W Steele, MD  more...
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The following are several important factors to consider in making treatment decisions about when to initiate antiretroviral therapy:

  • Severity of HIV disease

  • Risk of disease progression

  • Laboratory assessments (eg, CD4+ count, plasma HIV RNA levels)

  • Availability of appropriate and palatable drug formulations

  • Adverse effects of the antiretroviral medications

  • Effect of initial treatment regimen choice on later therapeutic options

  • Presence of comorbidities that may affect drug choices

  • Potential antiretroviral drug interactions with required concomitant medications

  • Ability of the child and caregiver to adhere to treatment regimen

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