How effective is antiretroviral therapy (ART) in the treatment of pediatric HIV infection?

Updated: Mar 05, 2020
  • Author: Delia M Rivera, MD; Chief Editor: Russell W Steele, MD  more...
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Answer

Reduction in the mortality rate associated with perinatally acquired HIV-1 over the past 10 years is a result of improved ART. However, only triple combination ART appears to significantly reduce the relative hazard ratio of death, as compared with no treatment.

The inadequacy of merely reducing the viral load has been realized in recent years. Quick suppression of the viral load with highly active ART (HAART) substantially slows viral replication and prevents resistant mutations.


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