Which conditions are included in clinical category C in pediatric HIV infection?

Updated: Mar 05, 2020
  • Author: Delia M Rivera, MD; Chief Editor: Russell W Steele, MD  more...
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Answer

Category C includes children who have any condition listed in the 1987 surveillance case definition for AIDS, with the exception of LIP (which is a category B condition). These conditions are as follows:

  • Serious bacterial infections, multiple or recurrent (ie, any combination of at least 2 culture-confirmed infections within a 2-y period), of the following types: septicemia, pneumonia, meningitis, bone or joint infection, or abscess of an internal organ or body cavity (excluding otitis media, superficial skin or mucosal abscesses, and indwelling catheter-related infections)

  • Candidiasis, esophageal or pulmonary (bronchi, trachea, lungs)

  • Coccidioidomycosis, disseminated (at site other than or in addition to lungs or cervical or hilar lymph nodes)

  • Cryptococcosis, extrapulmonary

  • Cryptosporidiosis or isosporiasis with diarrhea persisting greater than 1 month

  • Cytomegalovirus disease with onset of symptoms at older than 1 month (at a site other than liver, spleen, or lymph nodes)

  • Encephalopathy (at least one of the following progressive findings present for at least 2 mo in the absence of a concurrent illness other than HIV infection that could explain the findings): Failure to attain or loss of developmental milestones or loss of intellectual ability, verified by standard developmental scale or neuropsychological tests; impaired brain growth or acquired microcephaly demonstrated by head circumference measurements or brain atrophy demonstrated by CT scanning or MRI (serial imaging required for children < 2 y); acquired symmetric motor deficit manifested by 2 or more of the following: paresis, pathologic reflexes, ataxia, or gait disturbance

  • Herpes simplex virus infection causing a mucocutaneous ulcer that persists for greater than 1 month; or bronchitis, pneumonitis, or esophagitis for any duration affecting a child older than 1 month

  • Histoplasmosis, disseminated (at a site other than or in addition to lungs or cervical or hilar lymph nodes)

  • Kaposi sarcoma

  • Lymphoma, primary, in brain

  • Lymphoma, small, noncleaved cell (Burkitt), or immunoblastic or large cell lymphoma of B-cell or unknown immunologic phenotype

  • Mycobacterium tuberculosis, disseminated or extrapulmonary

  • Mycobacterium, other species or unidentified species, disseminated (at a site other than or in addition to lungs, skin, or cervical or hilar lymph nodes)

  • M avium complex or M kansasii, disseminated (at site other than or in addition to lungs, skin, or cervical or hilar lymph nodes)

  • Pneumocystis jiroveci pneumonia

  • Progressive multifocal leukoencephalopathy

  • Salmonella (nontyphoid) septicemia, recurrent

  • Toxoplasmosis of the brain with onset at older than 1 month

  • Wasting syndrome in the absence of a concurrent illness other than HIV infection that could explain the following findings: Persistent weight loss of >10% of baseline OR Downward crossing of at least 2 of the following percentile lines on the weight-for-age chart (eg, 95th, 75th, 50th, 25th, 5th) in a child aged 1 year or older OR Less than the 5th percentile on weight-for-height chart on 2 consecutive measurements, 30 days or greater apart PLUS 1) chronic diarrhea (ie, ≥2 loose stools/d for >30 d) OR 2) documented fever (for ≥30 d, intermittent or constant)


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