What are clinical categories of pediatric HIV infection?

Updated: Mar 05, 2020
  • Author: Delia M Rivera, MD; Chief Editor: Russell W Steele, MD  more...
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Answer

Clinical categories are based on the 2010 CDC guidelines [3] for antiretroviral treatment of pediatric AIDS (review and modification of the 1994 CDC HIV pediatric classification system for clinical categories in children younger than 13 y). This system uses a clinical-category letter and an immunologic number to note each stage of disease progression. The clinical categories are based on clinic manifestations. The immunologic category is based on the age-dependent CD4+ count (see Table 1, below).

Clinical categories include the following:

  • N – Not symptomatic

  • A – Mildly symptomatic

  • B – Moderately symptomatic

  • C – Severely symptomatic.

Table 1. CDC Immunologic Categories for HIV-Infection in Children Based on Absolute CD4+ Counts (Open Table in a new window)

Category

 

< 1 y

1-5 y

6-12 y

1 - No suppression

≥1500 (>25)

≥1000 (>25)

≥500 (>25)

2 - Moderate suppression

750-1499 (15-24)

500-999 (15-24)

200-499 (15-24)

3 - Severe suppression

< 750 (< 15)

< 500 (< 15)

< 200 (< 15)


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