What is the progression of lymphoid interstitial pneumonitis (LIP) in pediatric HIV infection/AIDS and how is it treated?

Updated: Mar 05, 2020
  • Author: Delia M Rivera, MD; Chief Editor: Russell W Steele, MD  more...
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Patients are usually asymptomatic at first, but cough and shortness of breath develop as lymphoid interstitial pneumonitis progresses. Hypoxia typically responds to a 2-week course of steroids, but oxygen dependence develops if an underlying chronic lung disease exists. Lymphoid interstitial pneumonitis increases the risk of bacterial pneumonia, especially with Haemophilus influenzae and pneumococcus.

Recurrent pneumonia destroys lung tissue and leads to chronic lung disease. Chest radiographs demonstrate chronic changes, including areas of chronic atelectasis. This condition requires management by a pulmonologist. Chronic respiratory therapy may be required, including home oxygen therapy.

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