Which resistance assays can be performed in the workup of pediatric HIV infection?

Updated: Mar 05, 2020
  • Author: Delia M Rivera, MD; Chief Editor: Russell W Steele, MD  more...
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Answer

Both genotypic and phenotypic assays can be performed. Genotypic assays are fast and available, but they reveal only known mutations, and they cannot be used to predict complex interactions when several antiretroviral drugs (ARDs) are used together.

Automated recombinant phenotypic assays are commercially available, but the results require additional time to be ready, and the tests are expensive. However, these assays can be used to detect complex interactions between ARDs and quasispecies, to perform in vitro drug trials, and to measure ART inhibitory concentrations.


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