What is the most common opportunistic infection in vertically transmitted HIV infection?

Updated: Mar 05, 2020
  • Author: Delia M Rivera, MD; Chief Editor: Russell W Steele, MD  more...
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Answer

PCP is the most common opportunistic infection in children with vertically transmitted HIV infection unless antibiotic prophylaxis is used. Without prophylaxis, PCP commonly occurs in infants aged 3 months. Without prophylactic suppression, infection may develop in infants younger than 1 year regardless of their baseline CD4+ count because the rapid progression of immunosuppression may precipitate a sharp decrease in their CD4+ counts.

PCP typically occurs in children with moderate immune suppression; this warrants category C classification.


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