Which factors are associated with rapidly progressive HIV disease in infants?

Updated: Mar 05, 2020
  • Author: Delia M Rivera, MD; Chief Editor: Russell W Steele, MD  more...
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Answer

The following factors are associated with rapidly progressive disease in infants:

  • Advanced maternal disease

  • High maternal viral load

  • Low maternal CD4+ count

  • Prematurity

  • In utero transmission

  • High viral load in the first 2 months of life

  • Lack of neutralizing antibodies

  • Presence of p24 antigen

  • AIDS-defining illnesses

  • Early cytomegalovirus (CMV) infection

  • Early neurologic disease

  • Failure to thrive

  • Early-onset diarrhea


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