Why does human immunodeficiency virus (HIV) resistance develop?

Updated: Mar 05, 2020
  • Author: Delia M Rivera, MD; Chief Editor: Russell W Steele, MD  more...
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HIV resistance develops because of low antiretroviral drug (ARD) levels due to several factors including variations in drug absorption and metabolism and noncompliance because of adverse effects or a poor understanding of the importance of the medication. Viral sanctuary sites may be exposed to low levels of ARDs, and resistant quasispecies may develop.

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