What are the mechanisms of viral resistance development in the HIV infection?

Updated: Mar 05, 2020
  • Author: Delia M Rivera, MD; Chief Editor: Russell W Steele, MD  more...
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Answer

In terms of the mechanisms of resistance development, the rapid turnover rate and high error rate of reverse transcriptase induces 3300 new single mutations per day. When a mutation improves the survival of the virus in an existing drug environment, that quasispecies is selected to reproduce. The higher the viral load and the higher the rate of replication, the greater the number of resistant quasispecies. Quasispecies can be transmitted to a fetus or neonate.


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