How common is neutropenia in HIV infection and what is its etiology?

Updated: Mar 05, 2020
  • Author: Delia M Rivera, MD; Chief Editor: Russell W Steele, MD  more...
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Answer

Neutropenia is observed in 10% of patients with early asymptomatic HIV infections and in 50% of patients with AIDS. Neutropenia results from the aforementioned mechanisms, as well as from medication. Granulocyte-macrophage colony-stimulating factor (GM-CSF) and G-CSF deficiencies not only reduce neutrophil production but also reduce granulocytic and monocytic function. GM-CSF and G-CSF promote increased neutrophilic function, including superoxide production, phagocytosis, intracellular killing, and antibody-dependent cellular cytotoxicity.


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