Which medications in the drug class Fibrinolytic Agent are used in the treatment of Thoracic Outlet Syndrome?

Updated: Jan 10, 2019
  • Author: Daryl A Rosenbaum, MD; Chief Editor: Sherwin SW Ho, MD  more...
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Answer

Fibrinolytic Agent

Thrombolytics are used to promote fibrinolysis of intraluminal thrombus or embolus in occluded vessels.

Urokinase (Activase)

Direct plasminogen activator that acts on endogenous fibrinolytic system and converts plasminogen to the enzyme plasmin, which, in turn, degrades fibrin clots, fibrinogen, and other plasma proteins. The advantage is that the agent is nonantigenic.

Most often used for local fibrinolysis of thrombosed catheters and superficial vessels. When used for local fibrinolysis, urokinase is given as local infusion directly into the area of thrombus and with no bolus given.

The dose should be adjusted to achieve clot lysis or patency of the affected vessel.


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