How is dexamethasone administered in the treatment of croup?

Updated: Oct 09, 2019
  • Author: Germaine L Defendi, MD, MS, FAAP; Chief Editor: Russell W Steele, MD  more...
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Answer

Dexamethasone has shown the same efficacy if administered intravenously (IV), intramuscularly (IM), or orally (PO). [35] The route of administration is patient-dependent as based on the patient’s age, ability to tolerate orals, and severity of presenting illness. The use of inhaled corticosteroids (budesonide) with systemic treatment has not shown additional benefit. [36]

Patients given a single oral dose of prednisolone (1 mg/kg) were found to have made more return visits, than those patients who received a single oral dose of dexamethasone (0.15 mg/kg). [37] This is due to the lesser potency to reduce inflammation and shortened half-life of prednisolone (18-36 h), when compared with dexamethasone (36-54 h).


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