Which medications in the drug class Clotting factor concentrates are used in the treatment of Pediatric Factor VII Deficiency?

Updated: Jun 22, 2021
  • Author: Helge Dirk Hartung, MD; Chief Editor: Hassan M Yaish, MD  more...
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Answer

Clotting factor concentrates

Clotting factor concentrates promote hemostasis by providing the deficient clotting factor to the coagulation cascade. Used for control and prevention of hemorrhagic episodes and surgical prophylaxis in patients with factor VII (FVII) deficiency.

Factor VIIa, recombinant (FVII Concentrate)

Vitamin K–dependent glycoprotein that promotes hemostasis by activating extrinsic pathway of coagulation cascade. FVII concentrates, available from Baxter or Bio Products Laboratory (United Kingdom), are purified plasma–derived concentrates that have undergone viral inactivation with vapor heat.

Coagulation FVIIa, recombinant (NovoSeven)

Activated FVII promotes hemostasis by activating the extrinsic pathway of coagulation cascade. Originally developed to treat patients with FVIII inhibitors. Doses lower than those recommended for patients with hemophilia are usually effective in patients with FVII deficiency.


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