What is the role of surgery in the treatment of pediatric factor VII deficiency?

Updated: Jun 22, 2021
  • Author: Helge Dirk Hartung, MD; Chief Editor: Hassan M Yaish, MD  more...
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Answer

Maintaining factor VII levels of at least 15-25% provides adequate hemostasis levels for most surgical procedures. [11]

Preoperative factor VII replacement and monitoring of factor VII levels is essential for major surgical interventions.

Because of the short half-life (3-4 h), replacement therapy should continue postoperatively; the period of therapy is determined by the nature and extent of the procedure.

A literature review by Rajpurkar and Cooper indicated that in patients with congenital factor VII deficiency, continuous infusion with rFVIIa can be a safe and effective alternative to bolus injection for perioperative bleeding management. The review included 26 patients with the deficiency, who received the treatment over a total of 46 major and minor surgeries. [12]


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