Which physical findings are characteristic of pediatric factor VII deficiency?

Updated: Jun 22, 2021
  • Author: Helge Dirk Hartung, MD; Chief Editor: Hassan M Yaish, MD  more...
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Answer

The physical manifestations are related to bleeding and include the following:

  • Mucosal bleeding: Epistaxis and bleeding from the oral cavity or GI tract have been observed.

  • Menorrhagia and associated anemia

  • Hemarthrosis: Patients with hemarthrosis have the same clinical presentation as those with hemophilia. Recurrent hemarthroses can lead to joint damage and chronic arthropathy.

  • Bruising, soft tissue hematomas

  • Neurologic findings commensurate with CNS bleeding, particularly in infants


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