How is pediatric factor VII deficiency classified?

Updated: Jun 22, 2021
  • Author: Helge Dirk Hartung, MD; Chief Editor: Hassan M Yaish, MD  more...
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However, using data from the European Network of Rare Bleeding Disorders (EN-RBD) registry, the International Society on Thrombosis and Haemostasis devised what Jain et al reported to be an effective classification scheme for congenital factor VII deficiency based on factor VII activity. Classification is as follows [5] :

  • Severe - Factor VII activity of less than 10%; risk of spontaneous major bleeding
  • Moderate - Factor VII activity of 10-20%; risk of mild spontaneous or triggered bleeding
  • Mild - Factor VII activity of 20-50%; primarily asymptomatic

Intrinsic and extrinsic pathways of coagulation are shown in the image below.

Intrinsic and extrinsic pathways of coagulation. F Intrinsic and extrinsic pathways of coagulation. Factor VII/tissue factor complex activates factor IX and factor X. Factor IXa along with factor VIIIa results in formation of more factor Xa. Factor Xa along with factor Va converts prothrombin to thrombin.

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