How are patients with pediatric factor XIII (FXIII) deficiency undergoing surgical procedures managed?

Updated: Mar 15, 2019
  • Author: Helge Dirk Hartung, MD; Chief Editor: Cameron K Tebbi, MD  more...
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Answer

In preparation for surgical procedures, patients should receive factor XIII concentrate immediately before surgery to ensure optimal hemostasis and wound healing.

A retrospective study of perioperative acquired factor XIII deficiency by Fahlbusch et al found that in pediatric patients undergoing cardiopulmonary bypass, neither preoperative nor postoperative factor XIII activity accurately predicted the need for postoperative transfusion. There was also no link seen between factor XIII activity and postoperative chest tube drainage loss. [10]


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