What is the role of immunologic assays in the workup of pediatric factor XIII (FXIII) deficiency?

Updated: Mar 15, 2019
  • Author: Helge Dirk Hartung, MD; Chief Editor: Cameron K Tebbi, MD  more...
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Answer

Factor XIIIa and factor XIIIb antigen levels can be quantified by means of enzyme-linked immunosorbent assay (ELISA).

Patients with subunit A mutations have less than 2% of the reference range levels of A antigen.

The rare individuals with B subunit mutations have low B antigen levels, and, because of the shorter half-life of the A subunit in the absence of the B subunit, the A subunit antigen levels are also reduced.


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