What is the role of multimer analysis in the workup of pediatric von Willebrand disease (VWD)?

Updated: Feb 05, 2019
  • Author: Suchitra S Acharya, MD, MBBS; Chief Editor: Hassan M Yaish, MD  more...
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Answer

In multimer analysis to determine the physical structure of von Willebrand factor (ie, whether high–molecular-weight multimers are present), plasma is electrophoresed through agarose gel. The presence or absence of high–molecular-weight von Willebrand factor is used to classify von Willebrand disease. Absence or decreased levels of high–molecular-weight von Willebrand factor multimers is consistent with type 2 von Willebrand disease. Further analysis of von Willebrand factor subunits has been performed with sophisticated electrophoretic techniques, resulting in the description of many type 2 variants.


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