What is the role of von Willebrand factor levels in the workup of pediatric von Willebrand disease (VWD)?

Updated: Feb 05, 2019
  • Author: Suchitra S Acharya, MD, MBBS; Chief Editor: Hassan M Yaish, MD  more...
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Answer

von Willebrand factor levels vary and can be influenced by numerous factors, including stress, inflammation, and blood type. Individuals with type O blood have lower values of von Willebrand factor levels on average, whereas those with type AB blood have higher values of von Willebrand factor.

Day-to-day variation in von Willebrand factor levels is a normal occurrence in the same individual; therefore, a single level within the reference range does not exclude the diagnosis of von Willebrand disease. Also, estrogen levels increase von Willebrand factor and may affect results in adolescent females and women with menorrhagia. Therefore, in the presence of significant bleeding symptoms, testing to rule out von Willebrand disease may need to be repeated several times.


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