How is pediatric von Willebrand disease (VWD) diagnosed?

Updated: Feb 05, 2019
  • Author: Suchitra S Acharya, MD, MBBS; Chief Editor: Hassan M Yaish, MD  more...
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Many children with von Willebrand disease (VWD) are asymptomatic and are diagnosed as a result of a positive family history or during routine preoperative screening. Some children may have completely normal screening and yet bleed at procedures in areas with increased fibrinolysis, such as the mouth (ie, tonsillectomy). Importantly, remember that a wide variation in clinical manifestations is observed, even for members of the same family.

The diagnosis of von Willebrand disease can be challenging and depends on an accurate personal and family bleeding history, as well as demonstration of a low von Willebrand factor (VWF) level. [9, 10]

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