Which medications in the drug class Nonsteroidal Anti-inflammatory Drugs are used in the treatment of Pars Interarticularis Injury?

Updated: Jan 22, 2019
  • Author: Gerard A Malanga, MD; Chief Editor: Craig C Young, MD  more...
  • Print
Answer

Nonsteroidal Anti-inflammatory Drugs

NSAIDs have analgesic, anti-inflammatory, and antipyretic activities. The mechanism of action of these agents is not known, but NSAIDs may inhibit cyclooxygenase activity and prostaglandin synthesis. Other mechanisms may include leukotriene synthesis inhibition, lysosomal enzyme release, lipoxygenase activity, neutrophil aggregation and various cell membrane functions.

Ibuprofen (Ibuprin, Motrin)

DOC for patients with mild to moderate pain. Inhibits inflammatory reactions and pain by decreasing prostaglandin synthesis. The anti-inflammatory dose is higher than the analgesic dose. Newer generation NSAIDs have a lower risk of gastrointestinal risk because they selectively interact with COX–2 receptors. Prolonged use of the medication is generally not recommended.

Celecoxib (Celebrex)

Inhibits primarily COX-2. COX-2 is considered an inducible isoenzyme, induced by pain and inflammatory stimuli. Inhibition of COX-1 may contribute to NSAID GI toxicity. At therapeutic concentrations, COX-1 isoenzyme is not inhibited, thus, GI toxicity may be decreased. Seek the lowest dose of celecoxib for each patient.

Naproxen (Naprosyn, Naprelan, Anaprox)

For relief of mild to moderate pain. Inhibits inflammatory reactions and pain by decreasing the activity of COX, which is responsible for prostaglandin synthesis.


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!