Which conditions are included in the differential diagnoses of Langerhans cell histiocytosis (LCH)?

Updated: Sep 16, 2020
  • Author: Cameron K Tebbi, MD; Chief Editor: Vikramjit S Kanwar, MBBS, MBA, MRCP(UK), FAAP  more...
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Answer

Establishing a diagnosis of Langerhans cell histiocytosis (LCH) largely depends on a high degree of suspicion. With the widely varied presentations of histiocytosis disorders, the differential diagnosis can be broad. Clinical differential diagnoses range from seborrheic dermatitis and chronic otitis media to acute leukemias, lymphomas, myeloproliferative disorders, storage diseases, Rosai-Dorfman syndrome, and solid tumors.


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