What is the global prevalence of Langerhans cell histiocytosis (LCH)?

Updated: Sep 16, 2020
  • Author: Cameron K Tebbi, MD; Chief Editor: Vikramjit S Kanwar, MBBS, MBA, MRCP(UK), FAAP  more...
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Answer

The overall incidence of Langerhans cell histiocytosis is estimated to be 4-10 per million population. However, because many bone and skin lesions may not be diagnosed as Langerhans cell histiocytosis, this rate may be an underestimate. [47] The estimated incidence of neonatal Langerhans cell histiocytosis, [48] determined by using the population-based German Childhood Cancer Registry, is 1-2 per million neonates.


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