Which histologic findings are characteristic of pediatric chronic granulomatous disease (CGD)?

Updated: Aug 07, 2019
  • Author: Lawrence C Wolfe, MD; Chief Editor: Cameron K Tebbi, MD  more...
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Answer

The two most frequent findings on histologic examination of the lesions observed in chronic granulomatous disease are infection and postinfectious granulomas.

Frequent sites of infection are the skin, lymph nodes, lungs, liver, spleen, bones, and joints; the brain and the GI and genitourinary (GU) tracts are less commonly involved.

Histologic findings consist of suppurative lesions with collections of phagocytic cells, predominantly neutrophils, with the causative bacteria or fungi and abscess formation.

Granulomatous involvement of the GI and GU tracts is not uncommon. Biopsy of these lesions shows necrotic granulomas with pigmented histiocytes and macrophages. These are most often sterile.

Similar granulomatous infiltrations of the skin and lungs are described.


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