Which lab findings are characteristic of pediatric chronic granulomatous disease (CGD)?

Updated: Aug 07, 2019
  • Author: Lawrence C Wolfe, MD; Chief Editor: Cameron K Tebbi, MD  more...
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Answer

Other laboratory findings

Other than the specific tests of phagocyte oxidative metabolism that help in establishing the diagnosis, no consistent or characteristic laboratory findings define this disease.

Most patients have WBC counts that are within the reference range or elevated, with further increases during infectious episodes.

Phagocyte morphology, phagocytic cell-surface adhesion proteins, chemotaxis, and phagocytosis are normal.

Patients may have anemia of chronic disease.

The erythrocyte sedimentation rate can be elevated even between infections.

Hypergammaglobulinemia is a common feature of the illness and is believed to represent a host response to recurrent or persistent infection.


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